Researchers of the Human Brain Project (HBP) have published a new study in Science Translational Medicine presenting advanced brain modeling methods for epilepsy clinical care. The article, which is featured on this week’s cover of the journal, describes the methodology used in the EPINOV clinical trial (Improving Epilepsy surgery management and progNOsis using Virtual brain technology).
The personalized brain modeling approach has been developed over several years in the HBP and is supported by the digital research infrastructure EBRAINS.
To create personalized brain models, the researchers use a simulation technology called The Virtual Brain (TVB), which HBP scientist Viktor Jirsa has developed together with collaborators. For each patient, the computational models are created from individually measured anatomy, structural connectivity, and brain dynamics data.
For epilepsy, the approach is currently being tested in a large-scale clinical trial to provide a computational, predictive tool in surgery preparation
Even though for many patients, epileptic seizures can be controlled by drugs, almost one-third of patients do not respond to medication. For this group, surgical removal of the epileptogenic zone, the brain area from which the seizure originates and propagates, presents the only treatment option. Currently, the procedure has a 60% success rate.
The TVB technology enables clinicians to simulate the spread of abnormal activity during epileptic seizures in a patient’s brain, helping them to identify the target areas better. The simulations are personalized for each patient, effectively providing a virtual epileptic patient (VEP) tailored to each individual real one. The approach has been tested in several retrospective studies, the latest one published this year in Epilepsia. The clinical trial is expected to run until 2025.
Ongoing work in the HBP uses the EBRAINS research infrastructure to further improve the method’s predictive power with new high-resolution data from the HBP’s multilevel human brain atlas.
“Computational neuro medicine needs to integrate high-resolution brain data and patient specificity,” explains Jirsa. “Our approach heavily relies on the research technologies in EBRAINS and could only have been possible in a large-scale, collaborative project such as the HBP.”
more recommended stories
Increased Screening Increases Rate of Gestational Diabetes
There have been reports of an.
Tumor Removal Could Get Easy with Advanced Imaging
The distinction between cancerous tumors and.
New Findings in Batten Disease Drug Research
According to RUSH researchers, the FDA-approved.
SARS-CoV-2 infection Enabler Genes Identified
Researchers from Weill Cornell Medical and.
First Possible Case of Mixed Race Woman Cured of HIV
Scientists report that a novel approach.
Multiple Sclerosis Risk Stays Undetected in Children
According to a Rutgers study, the.
Females With Unexplained Infertility Are More Prone To Cancer, Heart Disease
According to research from the Medical.
Equine-Facilitated Therapy to Help Low Back Pain Patients
A recent study from the University.
Study: Two Mutations Team Up To Hide Brain Cancer
An emerging class of immunotherapy medications.
New Way To Clear Toxic Proteins Linked to Alzheimer’s
The most prevalent form of dementia,.
Leave a Comment