Axicabtagene ciloleucel (axi-cel) appears to be both safe and effective for treating relapsed/refractory follicular lymphoma (FL), according to research presented at the European Hematology Association (EHA) 2021 Virtual Congress.
The phase 2 ZUMA-5 trial (ClinicalTrials.gov Identifier: NCT03105336) previously demonstrated that axi-cel, a chimeric antigen receptor (CAR)-T cell therapy targeting CD19, showed a both high overall response rate and long duration of response in patients with relapsed/refractory FL, including in patients with high-risk disease.
In this presentation, the authors reported comparative clinical outcomes from updated ZUMA-5 data and the international SCHOLAR-5 cohort.
Data from the SCHOLAR-5 cohort were taken from 7 institutions, and included data from a previous trial of idelalisib; patients in SCHOLAR-5 had received a third-line or later therapy after July 2014. Patient characteristics were balanced between the ZUMA-5 and SCHOLAR-5 cohorts.
Overall, data from 86 patients in ZUMA-5 and 85 patients in SCHOLAR-5 were included; the median follow-up times were 23.3 months and 26.2 months, respectively. Patients in the SCHOLAR-5 cohort had more patients with an Eastern Cooperative Oncology Group score of 1 at baseline, despite attempts to match characteristics.
In patients who had received at least 2 prior therapy lines, the overall response rates were 49.9% in SCHOLAR-5 vs 94.2% in ZUMA-5 (odds ratio, 16.2; 95% CI, 5.6-46.9). The median progression-free survival and overall survival periods were not reached in ZUMA-5, and were 12.7 months and 59.8 months, respectively, in SCHOLAR-5; the corresponding hazard ratios for progression-free and overall survival were 0.30 (95% CI, 0.18-0.49) and 0.42 (95% CI, 0.21-0.83), respectively.
“These data support that axi-cel represents a significant improvement in treatment options for patients with relapsed/refractory FL,” the presenter said.
Disclosure: The presenter declared affiliations with AstraZeneca, Kite, A Gilead Company, Gilead, Abbvie, Bristol Myers Squibb, MorphoSys, Novartis, Takeda, TG Therapeutics, Janssen.
Reference
Ghione P, Anik Patel A, Bobillo S, et al. A comparison of clinical outcomes from ZUMA-5 (axicabtagene ciloleucel) and the international SCHOLAR-5 external control cohort in relapsed/refractory follicular lymphoma (R/R FL). Paper presented at: European Hematology Association 2021 Virtual Congress; June 2021; Abstract LB1904.
The post Relapsed, Refractory Follicular Lymphoma: CAR-T Cell Therapy Shows Promise appeared first on Cancer Therapy Advisor.
more recommended stories
Surgeons Slow to Adopt Biomaterials for Bone DefectsTwo million bone transplants are performed.
Silver Showerheads May Promote Biofilms & ResistanceTo protect against hazardous waterborne germs,.
Kaempferol: A Breakthrough in Allergy ManagementKaempferol, a dietary flavonoid found in.
Early Milk Cereal Drinks May Spur Infant Weight GainNew research published in Acta Paediatrica.
Gaps in Gestational Diabetes Diagnosis in Pregnant WomenAccording to research on gestational diabetes.
TaVNS: A Breakthrough for Chronic Insomnia TreatmentA recent study conducted by the.
How LLMs Fake Personality for Better ResultsPersonality tests reveal that large language.
First-of-Its-Kind Gene-Edited Pig Kidney: Towana’s New LifeSurgeons at NYU Langone Health have.
Just-in-Time Training Improves Success & Patient SafetyA study published in The BMJ.
Decreased Alzheimer’s Disease Risk Among DriversA new study led by researchers.
Leave a Comment