

A recent study conducted by the China Academy of Chinese Medical Sciences (CACMS) at the Acupuncture and Moxibustion Hospital has explored the potential benefits of transcutaneous auricular vagus nerve stimulation (taVNS) for chronic insomnia. The study demonstrated that taVNS could significantly improve sleep quality in individuals suffering from this condition. Chronic insomnia affects a large portion of the adult population worldwide, causing issues like fatigue, mood disturbances, cognitive impairment, and excessive sleepiness.
taVNS is a non-invasive treatment method where small electrodes are placed on the outer ear to stimulate the auricular branch of the vagus nerve, aiming to enhance nerve function. Prior research has shown that taVNS can offer relief from conditions such as depression, epilepsy, and migraines, with recent studies suggesting its efficacy in addressing insomnia as well. However, previous evidence supporting taVNS for insomnia has been sparse and lacked rigorous clinical trials.
Chronic Insomnia Study
In this study, titled “Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Insomnia Disorder: A Randomized Clinical Trial,” 72 adults with chronic insomnia were randomly assigned to receive either active taVNS or a placebo treatment. The participants underwent 30-minute self-administered stimulation sessions twice daily for eight weeks. After the study, the taVNS group showed significant improvements in sleep quality, as measured by the Pittsburgh Sleep Quality Index (PSQI), and these improvements were sustained during the 12-week follow-up period.
Moreover, the taVNS group demonstrated reductions in insomnia severity, anxiety, depression, and fatigue. Despite these promising results, the study has faced criticism regarding its adherence to the registered trial protocol. The trial initially aimed to use multimodal MRI to observe the brain’s response to taVNS, but no MRI data was provided, raising concerns about the study’s transparency and legitimacy.
While taVNS appears to offer a viable non-pharmacological option for insomnia treatment, these protocol deviations should be addressed to ensure the study’s credibility. Attending Sleep Medicine CME Courses helps healthcare professionals with the latest breakthroughs in healthcare.
More Information: Shuai Zhang et al, Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Insomnia Disorder, JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.51217
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