Bee-Sting Microneedle Patch for Painless Drug Delivery

Microneedle Patch: A Pain-Free Alternative for Long-Term Treatment

Millions of patients with neurological and chronic diseases depend on regular drug injections to manage their conditions. However, repeated needle use often causes discomfort, fear, and reduced treatment compliance. Researchers from Chung-Ang University, South Korea, have developed a new bee-sting-inspired microneedle patch designed to deliver medication painlessly and effectively over extended periods.

Unlike traditional microneedles, which are rigid and may irritate the skin, these Electrospun Web Microneedles (EW-MNs) are soft, breathable, and designed to stay securely in place, much like a bee stinger. This innovation offers a patient-friendly solution for continuous drug delivery without the anxiety associated with conventional needle injections.

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How EW-Microneedles Work: Inspired by Nature

The research team, led by Professor Wonku Kang and Dr. Sohee Jeon, created the microneedles using electrospinning technology, which forms nanoscale fibers around the needle tips. This structure mimics the natural barbed design of a bee stinger, allowing the microneedles to anchor gently yet firmly into the skin.

The EW-MNs are mounted on an adhesive patch, enabling controlled drug release over a wider area with minimal discomfort. In preclinical tests using guinea pigs, the patches were loaded with rivastigmine, a medication commonly used for Alzheimer’s and Parkinson’s disease. Results showed a two-fold increase in drug absorption and coverage of five times the skin area compared to traditional delivery methods.

Even when minor irritation occurred, it resolved quickly after the patch was removed, demonstrating the system’s potential for safe, long-term use.

“With further development, these EW-MNs could transform drug delivery, allowing patients to receive effective long-term treatments without the fear or discomfort of needles,” said Prof. Kang.

Future Potential Beyond Neurological Disorders

The EW-MN patch system has applications far beyond neurological diseases. The researchers envision its use for a range of chronic illnesses, offering a practical option for elderly patients, children, and individuals requiring safe, self-administered treatments.

This breakthrough represents a promising step toward needle-free drug delivery, potentially improving adherence, reducing healthcare burdens, and enhancing overall patient quality of life.

Source:

Chung Ang University