

Researchers from the Francis Crick Institute and Barts Cancer Institute have discovered why patients with a rare form of blood cancer have inefficient red blood cell formation and how vitamin B5 may be used in combination with already available medications to enhance outcomes.
Blood cancers known as myelodysplastic syndromes (MDS) are defined by a stem cell abnormality in which the formation of healthy red blood cells is disrupted. For some people, there are no curative treatments, however, some drugs can help the disease advance more slowly.
Most patients with this condition go on to acquire acute myeloid leukemia (AML), and within 18 to 2 years of treatment, about half of patients develop resistance to the available MDS medications. Because of an excess of iron in the blood, these patients are very dependent on red blood cell transfusions, which can be unpleasant and deadly. So, it’s critical to find novel approaches to treating this condition and halting the development of leukemia.
In their investigation, which was written up in Science Translational Medicine, the researchers examined blood samples from 42 myelodysplastic syndromes patients. Scientists discovered that the COASY enzyme plays a crucial role in controlling the generation of red blood cells in the bone marrow. Production of red blood cells is substantially hampered in MDS patients with partial absence of the enzyme causing anemia.
Next, they investigated if treatments like vitamin B5 supplementation could increase the creation of red blood cells. The maturation of red blood cells was accelerated by treatments with vitamin B5, or another molecule called succinyl-CoA.
Kevin Rouault-Pierre, Group Leader at Barts Cancer Institute and supervisor of the study, said, “Current treatments for MDS are often associated with reduced quality of life as well as the increased risk of progression to leukemia. Understanding the biology behind this stem cell disorder is key to unlocking new treatments of the future.”
“Our next steps will be to further investigate how to boost red blood cell production and work towards testing new treatments in clinical trials.”
Syed Mian, a postdoctoral research fellow in the Crick’s Haematopoietic Stem Cell Laboratory, who co-authored with Celine Philippe postdoctoral training fellow at Barts Cancer Institute, says, “Given our elderly population is increasing and age is the dominant risk factor for the development of MDS, we will start to see more and more people with this type of blood cancer.
“Anemia-related symptoms, such as chronic fatigue, are commonly reported in MDS and the current red blood cell transfusions, although essential, come with potential complications, and also require substantial human and financial resources. Therefore, it’s essential that we find alternative ways to regulate long-term red blood cell production in these patients. Our results may also potentially help with treatments of other diseases where patients commonly present with anemia.”
more recommended stories
New Study Questions Fluid Restriction in Heart Failure Management
A groundbreaking study presented at the.
Role of Leptin Signaling in the DMH for Metabolic Regulation
A groundbreaking study from the Pennington.
COVID-19 Vaccines May Lower the Risk of Long COVID by 27%
A recent rapid review suggests that.
3D-Printed Hydrogel for Meniscus Tear Treatment
Meniscus tears are one of the.
Machine Learning Predicts Early Mortality in IBD Patients
A groundbreaking study published in the.
Endometriosis Treatment Advances: Latest Research and Therapy
Recent endometriosis treatment advances are reshaping.
Lung Cancer Screening Gaps Persist Despite Updated Guidelines
A recent study led by researchers.
Altered Knee Movement After ACL Surgery May Trigger Early Osteoarthritis
A recent study published in the.
BRP Peptide for Weight Loss: A Natural Alternative to Ozempic?
The rising obesity epidemic has fueled.
Toxic Soil and Water Linked to Global Heart Disease Crisis
A groundbreaking review published in Atherosclerosis.
Leave a Comment