Carnivore Diet-Induced Cholesterol Deposits Alarm Doctors

Man on High-Fat Carnivore Diet Develops Yellowish Nodules on Skin
A man in his 40s developed yellowish nodules (build-up of cholesterol) on his hands, feet, and elbows after adhering to a carnivore diet, according to a report by cardiologists from Tampa General Hospital and the University of Texas MD Anderson Cancer Center. Their findings, published in JAMA Cardiology, reveal the dangers of extreme dietary practices.

The patient reported that the nodules appeared three weeks before seeking medical help. After thorough questioning, the doctors learned he had been following a high-fat carnivore diet for eight months, consuming nearly 10 pounds of butter, cheese, and other fatty foods daily. This diet, centered on excessive animal fat intake with minimal other food sources, led to alarmingly high cholesterol levels—approximately four times the normal range.

Tests confirmed the man had developed xanthelasma, a condition characterized by cholesterol deposits forming under the skin. In this advanced case, the cholesterol buildup had begun to break through the surface of his skin, causing visible and painless nodules on his palms, soles, and elbows.

The doctors advised the patient to reduce his fat intake immediately, but they noted that dietary changes alone would not eliminate the existing nodules. These would require surgical excision or removal via liquid nitrogen. Additionally, they warned him about the risks associated with extremely high cholesterol levels, including an increased likelihood of cardiovascular disease, stroke, and potential liver damage.

This case highlights the dangers of unbalanced diets that promote excessive consumption of specific food groups. Cardiologists emphasize the importance of balanced nutrition and caution against extreme dietary trends that may pose significant health risks.

More Information: Konstantinos Marmagkiolis et al, Yellowish Nodules on a Man Consuming a Carnivore Diet, JAMA Cardiology (2025). DOI: 10.1001/jamacardio.2024.5209