In both the United States and other parts of the world, kidney stones are becoming an increasingly regular occurrence. There is a correlation between type 2 diabetes and an increased risk of kidney stones; however, there are a variety of treatment options available for this condition that have the ability to minimize the risk of kidney stones formation.
The use of sodium-glucose contratransporter 2 (SGLT2) inhibitors was found to be connected with a reduced risk of developing kidney stones, according to the findings of researchers at Mass General Brigham. Their results were later reported in the journal JAMA Internal Medicine.
The investigation was carried out by researchers from Massachusetts General Hospital and Brigham and Women’s Hospital working together to undertake the investigation. The research incorporated information obtained from three national databases pertaining to individuals diagnosed with type 2 diabetes who were seen in the course of their regular clinical practice. In their study, the researchers looked at information from 716,406 people who had type 2 diabetes and had started taking either an SGLT2 inhibitor or one of two additional types of diabetes medications known as GLP1 receptor agonists or dipeptidyl peptidase 4 (DPP4) inhibitors.
In comparison to patients who were using GLP1 agonists, those who started taking SGLT2 inhibitors had a thirty percent lower risk of developing kidney stones, and those who started taking DPP4 inhibitors had a twenty-five percent lower risk altogether. The findings were constant regardless of factors such as gender, race or ethnicity, a previous history of chronic renal illness, or obesity.
“Our findings could help inform clinical decision making for patients with diabetes who are at risk of developing kidney stones,” said corresponding author Julie Paik, MD, ScD, MPH, of Brigham and Women’s Hospital’s Divisions of Pharmacoepidemiology and Pharmacoeconomics and Renal (Kidney) Medicine.
For more information: Sodium-Glucose Cotransporter 2 Inhibitors and Nephrolithiasis Risk in Patients With Type 2 Diabetes, JAMA Internal Medicine (2024). DOI: 10.1001/jamainternmed.2023.7660
more recommended stories
Daraxonrasib Approved for Metastatic Pancreatic CancerKey Points FDA approved daraxonrasib (RASONQUE).
Nicotine E-Cigarettes Help More Smokers Quit Than NRTKey Points Nicotine e-cigarettes helped more.
AI Identifies Key Gene Driving Hematopoietic Stem Cell AgingKey Points AI analysis identified Pbx1.
Intravenous Iron Improves Recovery After Heart SurgeryKey points A large multicenter randomized.
Childhood Epilepsy Linked to Lower Educational AchievementKey Takeaways Childhood epilepsy was associated.
Laser Treatment for Glioblastoma Shows Survival BenefitKey Points A multicenter analysis of.
Malaria Vaccination Turns Mosquito Bites Into Immune BoostersKey takeaways: WEHI researchers developed a.
Inhaled Cannabis Linked to Fewer Premature HeartbeatsKey Points Habitual cannabis users had.
Lead Exposure in Indoors and Contamination in SoilKey Points Lead contamination in soil.
Early-Life Stress Linked to Lasting Brain Epigenetic ChangesKey Points Early-life stress (ELS) increased.
Leave a Comment