Endometriosis: A Hidden Risk for Heart Disease

A recent study published in BMC Public Health highlights a concerning connection between endometriosis and an increased risk of cardiovascular diseases (CVDs). Endometriosis, a condition where tissue similar to the uterine lining grows outside the uterus, affects 5-10% of women worldwide, leading to chronic symptoms like pelvic pain and excessive bleeding. Women with endometriosis are at higher risk of conditions like hypertension, heart disease, and high cholesterol.

The study found that women with endometriosis face a 23% higher risk of CVD and a 13% increased risk of hypertension. Chronic inflammation, oxidative stress, and elevated estrogen levels are believed to contribute to these risks, as they can affect vascular health and promote the formation of atherosclerotic plaques. Additionally, lifestyle factors such as a poor diet and lack of exercise, common in both conditions, may further increase the risk of developing CVDs.

Previous studies have already indicated a relative risk increase for ischemic heart disease (IHD), hypertension, and myocardial infarction (MI) in patients with endometriosis. However, this study is the first meta-analysis to establish a clear connection between the condition and CVD risk, underscoring the importance of early cardiovascular screening and preventive care. Clinicians are urged to address these risks proactively by focusing on lifestyle changes, controlling inflammation, and managing hormonal imbalances in patients with endometriosis.

While the findings require further investigation to better understand the underlying mechanisms, they call for a more integrated approach to treating endometriosis, considering both reproductive and cardiovascular health.

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More Information: Parsa, S., Noroozpoor, R., Dehghanbanadaki, H., et al. (2025). Endometriosis and risk of cardiovascular disease: a systematic review and meta-analysis. BMC Public Health. doi:10.1186/s12889-025-21486-0.